Welcome to Dr. Yuqing Hou's Homepage

EDUCATION

• B.S.: July, 1985. Applied chemistry; Department of Materials and Fuels, National University of Defense Technology, Changsha, China.
• M.S.: July, 1988. Synthetic organic chemistry; Department of Chemistry, Hangzhou University, Hangzhou, China.
• PhD: December, 1997, organic chemistry; Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois.
• Postdoctoral fellow: December, 1997 - December, 1998. Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois.

EXPERIENCES

• 2000-present, Associate Director, Meyers Research Institute for Interdisciplinary Research in Organic and Medicinal Chemistry; Research Assistant Professor, Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois.
• December,1998-January, 2000 Assistant Scientist, Department of Chemistry and Biochemistry, Southern Illinois University at Carbondale, Carbondale, Illinois.
• 1991-1993, chief engineer, Division of polyurethanes, Liming Institute of Chemical Industry, Luoyang, China.
• 1990-1991, engineer, Division of polyurethanes, Liming Institute of Chemical Industry, Luoyang, China.
• 1988-1990, assistant engineer, Division of polyurethanes, Liming Institute of Chemical Industry, Luoyang, China.

AWARDS

• 1995-1996, doctoral fellowship, the Graduate School, Southern Illinois University, Carbondale
• 1996-1997, doctoral fellowship, the Graduate School, Southern Illinois University, Carbondale
• 1997-1998, dissertation award, the Graduate School, Southern Illinois University Carbondale

PROFESSIONAL AFFILIATION

• Member of American Chemical Society

PUBLICATIONS, PRESENTATIONS AND PATENTS

1. PUBLICATIONS

   1. Huang, X.; Hou, Y. Debromination of vic-Dibromoalkanes with Sodium O,O-Diethyl Phosphite Catalysed by Tellurium. Synth. Commun. 1988, 18, 2201-2205.
   2. Huang, X.; Hou, Y. A Convenient Route to a,b-Unsaturated Ketones - Reaction of wBromoacetophenone with Arylaldehydes Catalysed by Sodium O,O-Diethyl Phosphotelluroate. Youji Huaxue 1989, 9, 249-251.
   3. Hou, Y.; Huang, X. A Novel Synthesis of Unsymmetrical Diaryl Ditellurides. Synth. Commun. 1989, 19, 1267-1269.
   4. Meyers, C. Y.; Lutfi, H. G.; Kolb, V. M.; Hou, Y.; Robinson, P. D. Acetone 4,4- Dimethyl-5-oxo-2-pyrazolin-3-ylhydrazone. Acta Crystallogr. 1996, C52, 2367-2370.
   5. Meyers, C. Y.; Lutfi, H. G.; Hou, Y.; Robinson, P. D. Racemic 1,2,4-Trimethylurazole.Acta Crystallogr. 1997, C53, 98-100.
   6. Meyers, C. Y.; Hou, Y.; Scott, D.; Robinson, P. D. Exclusive Formation of Crystalline sp-9-(o-Isopropylphenyl)fluorene from its ap Rotamer in Solution. Acta Crystallogr.1997, C53, 1149-1151
   7. Meyers, C. Y., Hou, Y., Kolb, V. M.; Robinson, P. D. (1R,2R)-4-Methylurazole-a pyranosyl-2-deoxyriboside from Reaction of 4-Methylurazole with 2-Deoxy-D-ribose. Acta Crystallogr. 1997, C53, 1502-1505.
   8. Robinson, P. D.; Hou, Y., Lutfi, H. G.; Meyers, C. Y. Exclusivity of the sp Rotamers of 9-(o-tert-Butylphenyl)fluorene and 9-(o-tert-Butylphenyl)-9-fluorenol. Acta Crystallogr. 1998, C54, 73-77.
   9. Hou, Y.; Meyers, C. Y.; Robinson, P. D. sp-(R)-9-(o-t-Butylphenyl)-9-fluorenol-2-N-[(S)-a-methylbenzyl]carboamide·Acetone. A Novel 1:1 Cavitate. Acta Crystallogr. 1998, C54, 1013-1016.
   10. Robinson, P. D.; Hou, Y.; Meyers, C. Y. sp-9-[o-(b-Chloro-a,a-dimethylethyl)phenyl]-fluorene: Unanticipated Exclusive Product from the Reaction of sp-9-(o-tert-Butylphenyl)-9- fluorenol with Thionyl Chloride. Acta Crystallogr. 1998, C54, 1173-1175.
   11. Banz, W. J.; Winters, T. A.; Hou, Y.; Adler, S.; Meyers, C. Y. Comparative Effects of (-)-, (+)- and (±)-Z-Bisdehydrodoisynolic Acids and Estradiol on Body Weight, Food Intake and Metabolic Parameters in Male and Female Rats. Hormone and Metabolic Research, 1998, 30, 730-736.
   12. Schwendemann, T. C.; May, P. S.; Berry, M. T.; Hou, Y.; Meyers, C. Y. Effect of Ligand Deuteration on the Decay of Eu3+ (5D0) in Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)- europium(III). J. Phys. Chem. A, 1998, 102, 8690-8694.
   13. Robinson, P. D., Hou, Y. and Meyers, C. Y., sp-9-(o-tert-Butylphenyl)-3-methylthio-fluorene. A Major Rearrangement Product from the Facile Uncatalyzed Decomposition of ap-9-(o-tert-Butylphenyl)-9-methylthiylfluorene. Acta Crystallogr.1998, CIF access, Oct. DVN IUC 9800051.
   14. Meyers, C. Y., Hou, Y and Robinson, P. D., ap-9-(o-tert-Butylphenyl)-9-methanethiofluorene. The First Isolated ap Rotamer of a 9-Substituted 9-(o-tert-Butylphenyl)fluorene. Acta Crystallogr. 1999, C55, 626-628.
   15. Hou, Y.; Meyers, C. Y.; The surprising formation of structurally distorted ap-9-(o-tert- butylphenyl)-9-methylthiofluorene and its facile homolysis into sp-9-(o-tert-butylphenyl)-3-methylthiofluorene and sp-9-(o-tert-butylphenyl)fluorene. Can. J. Chem. , 1999, 77, 960-966.
   16. Robinson, P. D.; Hou, Y.; Meyers, C. Y.; Adler, S.; Banz, W. J.; Winters, T. A. L-Menthyl Ester of Highly Estrogenic (-)-Z-Bisdehydrodoisynolic Acid 3-Methyl Ether. Acta Crystallogr. 1999, C55, April, CIF access paper IUC9900020.
   17. Meyers, C. Y.; Hou, Y.; Hisham, H. G.; Saft, H. The First Reported Halogenation of a tert-Butyl Group with HCl or HBr in CHCl3. Unexpected Differences in the Reaction of HCl, HBr, HI, and HF with sp-9-(o-tert-Butylphenyl)-9-fluorenol. J. Org. Chem. 1999, 64, 9444-9449.
   18. Robinson, P.D.; Hou, Y.; Meyers, C. Y. ap-9-(o-Isopropylphenyl)-9-fluorenol. Acta Crystallogr. 1999, CIF access, Nov. IUC 9900144.
   19. Hou, Y.; Robinson, P.D.; Meyers, C. Y. ap-9-(o-Isopropylphenyl)-9-fluorenyl PeroxideActa Crystallogr. 1999, CIF access, Nov. IUC 9900147.
   20. Meyers, C. Y.; Hou, Y.; Robinson, P. D.; Adler, S.; Banz, W. J.; Winters, T. A. Absolute Structure Determination of the Highly Biologically Active Bisdehydrodoisynolic Acids. J. Pharm. Sci., 2000, 89, 513-518.
   21. Hou, Y.; Meyers, C. Y. The first one-pot asymmetric synthesis of esters of highly biologically active (+)- and (-)-3-[2-(6-methoxynaphthyl)]-2,2-dimethylpentanoic acid (Vallestril®). Archiv. Org. Chem., 2000, 1, 106-114.
   22. Meyers, C. Y., Lutfi, H. G., Varol, P., Hou, Y. and Robinson, P. D. Preparation and Surprising sp Rotameric Structure of 9-Methyl-9-pivaloylfluorene. Acta Crystallogr. 2000, C56 submitted May 19'00, ms No. GD 1104.
   23. Robinson, P. D., Lutfi, H. G., Hou, Y. and Meyers, C. Y. Unexpected Dipivaloylation of 9-lithiated fluorene. Formation of 9-(2',2'-dimethyl-1'-pivaloxypropylidine)fluorene. Acta Crystallogr. 2000, C56 submitted May 24 '00, ms No. BK1551.
   24. Wilson, T., March, H., Banz, W. J., Hou, Y., Adler, S., Meyers, C. Y., Winters, T.A. and Maher, M. A. Antioxidant Effects of Phyto- and Synthetic Estrogens on Cupric Ion-Induced Oxidation of Human Low Density Lipoproteins In Vitro. Biochemical Pharmacology, 2000, submitted May 2X, 2000.
   
   

2. ABSTRACTS IN PROFESSIONAL CONFERENCES

   1. Seyler, J. W.; Dunn, H. E.; Meyers, C. Y.; Hou, Y. Structural and Computational Studies on Rotamers of t-Butyl 9-fluorenyl Sulfone, Sulfoxide, and Sulfide, Meeting of the American Chemical Society-Indiana/Kentucky Border Section, University of Southern Indiana, Evansville, Indiana, March 18, 1995.
   2. Meyers, C. Y.; Lutfi, H. G.; Hou, Y.; Robinson, P. D. Enantiomer-Selective Intermolecular Hydrogen Bonding in Crystalline Urazoles. Effect on Crystallization Patterns, Melting Points, and Solubilities. American Chemical Society, National Meeting, Chicago, August 20-24, 1995; Abstract No. ORGN 296.
   3. Meyers, C. Y.; Hou, Y.; Lutfi, H. G.; Robinson, P. D. 9-Substituted Fluorene Rotomers. Investigation of NMR Spectra, X-Ray Crystal Structure, Reactivities, and Rotational and Configurational Stabilities. American Chemical Society, National Meeting, Chicago, August 20-24, 1995; Abstract No. ORGN 297.
   4. Meyers, C. Y.; Hou, Y.; Lutfi, H. G.; Robinson, P. D.; Dunn, H. E.; Seyler, J. W. 9-Substituted 9-(o-t-Butlphenyl)fluorene Rotamers: Reactivity, Dynamic NMR, X-Ray Crystal Structure and Theoretical Studies. American Chemical Society, National Meeting, San Francisco, April 13-17, 1997, Abstracts ORGN 351.
   5. Meyers, C. Y.; Hou, Y.; Scott, D.; Robinson, P. D.; Dunn, H. E.; Seyler, J.W. 9;9-Substituted 9-(o-i-Propylphenyl)fluorene Rotamers: Reactivity, Dynamic NMR, X-Ray Crystal Structure and Theoretical Studies. American Chemical Society, National Meeting, San Francisco, April 13-17, 1997, Abstracts ORGN 352.
   6. Banz, W. J.; Winters, T. A.; Hou, Y.; Meyers, C. Y.; Mallon, M. A.; Adler, S. Activities of Non-classical Estrogens: Effects of (-), (+), and (±) Z-Bisdehydrodoisynolic Acids in vitro and on Body Weight in Male and Female Rats. Abstract for The Endocrine Society Annual Meeting, New Orleans, June, 1998, Poster No. P1-552.
   7. Meyers, C. Y.; Hou, Y.; Sandrock, P.; Robinson, P. D.; Hua, D. H.; Chan-Yu-King, R. Solved: The Mesityl Isopropyl Sulfone Enigma. American Chemical Society, National Meeting, Boston, August, 1998, Abstract No. 637.
   8. Wilson, T.; March, H.; Banz, W. J.; Hou, Y.; Adler, S.; Meyers, C. Y. Winters, T. A.; Maher, M. A. Antioxidant Effects of Phyto- and Synthetic Estrogens on Cu⁺⁺-induced Oxidation of Human Low Density Lipoproteins (LDL). Abstract for Endocrinology - Reproductive Physiology Annual Symposium, Madison, Wisconsin, September 4, 1998.
   9. Suttner, A. M.; Banz, W. J.; Hou, Y.; Meyers, C. Y.; Adler, S.; Winters, T. A. The Effects of Z-bis-Dehydrodoisynolic Acids on in situ Apoptosis in Primary Porcine Granulosa Cells. Abstract for Endocrinology - Reproductive Physiology Annual Symposium, Madison, Wisconsin, September 4, 1998.
   10. Banz, W. J.; Winters, T. A.; Hou, Y.; Adler, S.; Meyers, C. Y. Comparative Effects of the Selective Estrogen Receptor Modulators (-)-, (+)-, and (±)-Z-bis-dehydrodoisynolic Acids on Metabolic and Reproductive Parameters in Male and Female Rats. Abstract for Endocrinology - Reproductive Physiology Annual Symposium, Madison, Wisconsin, September 4, 1998.
   11. Winters, T.; Banz, W.; Cameron, J.; McDearmon, M.; Debeljuk, L.; Huggenvik, J.; Collard, M.; Meyers, C.; Hou, Y.; Adler, S.; Dandliker, W.; Differential Effects of Estrogenic Carboxylic Acids on the Testis and Prostate. Federation of American Societies for Experimental Biology, Experimental Biology Meeting, San Diego, April 15-18, 2000.
   
   

3. PATENT APPLICATIONS

   1. Meyers, C. Y.; Adler, S.; Banz, W.; Hou, Y.; Dandliker, W. B.; Winters, T. Therapeutic Applications of Estrogenic Carboxylic Acids, Patent Application, U.S. Patent and Trademark Office, filed on June 23, 1999; Ser. No. 09/338,823.
   2. Meyers, C. Y.; Adler, S.; Banz, W.; Hou, Y.; Dandliker, W. B.; Winters, T. Therapeutic Applications of Estrogenic Carboxylic Acids, International Patent Application, filed on June 22, 1999; Ser. No. 60/090344.

HOBBIES

• Playing bridge and
• Playing table tennis
• Rollerblading